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1

Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): results from a randomised, phase 3 trial

Loriot, Yohann, Miller, Kurt, Sternberg, Cora N, Fizazi, Karim, De Bono, Johann S, Chowdhury, Simon, Higano, Celestia S, Noonberg, Sarah, Holmstrom, Stefan, Mansbach, Harry, Perabo, Frank G, Phung, De

Journal:

The Lancet Oncology

Year:

2015

Language:

english

File:

PDF, 752 KB

english, 2015

2

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology

Nuhn, Philipp, De Bono, Johann S., Fizazi, Karim, Freedland, Stephen J., Grilli, Maurizio, Kantoff, Philip W., Sonpavde, Guru, Sternberg, Cora N., Yegnasubramanian, Srinivasan, Antonarakis, Emmanuel S

Journal:

European Urology

Year:

2018

Language:

english

File:

PDF, 650 KB

english, 2018

3

Chemical or Surgical Castration—Is This Still an Important Question?

Kolinsky, Michael, Rescigno, Pasquale, de Bono, Johann S.

Journal:

Year:

2015

Language:

english

File:

PDF, 115 KB

english, 2015

4

Consensus on molecular imaging and theranostics in prostate cancer

Fanti, Stefano, Minozzi, Silvia, Antoch, Gerald, Banks, Ian, Briganti, Alberto, Carrio, Ignasi, Chiti, Arturo, Clarke, Noel, Eiber, Matthias, De Bono, Johann, Fizazi, Karim, Gillessen, Silke, Gledhill

Journal:

The Lancet Oncology

Year:

2018

Language:

english

File:

PDF, 419 KB

english, 2018

5

Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019

Gillessen, Silke, Attard, Gerhardt, Beer, Tomasz M., Beltran, Himisha, Bjartell, Anders, Bossi, Alberto, Briganti, Alberto, Bristow, Rob G., Chi, Kim N., Clarke, Noel, Davis, Ian D., de Bono, Johann,

Journal:

European Urology

Year:

2020

Language:

english

File:

PDF, 1.15 MB

english, 2020

6

Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer

Gerhardt Attard, Arie S. Belldegrun, Johann S. De Bono

Journal:

BJU International

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

7

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

Autiero, Monica, Waltenberger, Johannes, Communi, Didier, Kranz, Andrea, Moons, Lieve, Lambrechts, Diether, Kroll, Jens, Plaisance, Stephane, De Mol, Maria, Bono, Françoise

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 757 KB

english, 2003

8

Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

Johann Sebastian de Bono, Stephane Oudard, Mustafa Ozguroglu, Steinbjørn Hansen, Jean-Pascal Machiels, Ivo Kocak, Gwenaëlle Gravis, Istvan Bodrogi, Mary J Mackenzie, Liji Shen, Martin Roessner, Sunil

Journal:

Year:

2010

Language:

english

File:

PDF, 293 KB

english, 2010

9

Effect of enzalutamide on time to first skeletal-related event, pain, and quality of life in men with castration-resistant prostate cancer: results from the randomised, phase 3 AFFIRM trial

Fizazi, Karim, Scher, Howard I, Miller, Kurt, Basch, Ethan, Sternberg, Cora N, Cella, David, Forer, David, Hirmand, Mohammad, de Bono, Johann S

Journal:

The Lancet Oncology

Year:

2014

Language:

english

File:

PDF, 337 KB

english, 2014

10

Interview with Johann de Bono for Future Oncology

de Bono, Johann

Journal:

Future Oncology

Year:

2012

Language:

english

File:

PDF, 399 KB

english, 2012

11

Subsequent Chemotherapy and Treatment Patterns After Abiraterone Acetate in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302

de Bono, Johann S., Smith, Matthew R., Saad, Fred, Rathkopf, Dana E., Mulders, Peter F.A., Small, Eric J., Shore, Neal D., Fizazi, Karim, De Porre, Peter, Kheoh, Thian, Li, Jinhui, Todd, Mary B., Ryan

Journal:

European Urology

Year:

2016

Language:

english

File:

PDF, 561 KB

english, 2016

12

Metastatic Prostate Cancer

Longo, Dan L., Sartor, Oliver, de Bono, Johann S.

Journal:

New England Journal of Medicine

Year:

2018

Language:

english

File:

PDF, 172 KB

english, 2018

13

Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol

Sydes, Matthew R, Spears, Melissa R, Mason, Malcolm D, Clarke, Noel W, Dearnaley, David P, de Bono, Johann S, Attard, Gert, Chowdhury, Simon, Cross, Bill, Gillessen, Silke, Malik, Zaf, Jones, Rob, Par

Journal:

Annals of Oncology

Year:

2018

Language:

english

File:

PDF, 933 KB

english, 2018

14

Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer

Rescigno, Pasquale, Chandler, Robert, de Bono, Johann

Journal:

Current Opinion in Supportive and Palliative Care

Year:

2018

Language:

english

File:

PDF, 172 KB

english, 2018

15

Alternative splicing in prostate cancer

Paschalis, Alec, Sharp, Adam, Welti, Jonathan C., Neeb, Antje, Raj, Ganesh V., Luo, Jun, Plymate, Stephen R., de Bono, Johann. S.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2018

Language:

english

File:

PDF, 1.25 MB

english, 2018

16

Serum Free Methylated Glutathione S-transferase 1 DNA Levels, Survival, and Response to Docetaxel in Metastatic, Castration-resistant Prostate Cancer: Post Hoc Analyses of Data from a Phase 3 Trial

Mahon, Kate L., Qu, Wenjia, Lin, Hui-Ming, Spielman, Calan, Cain, Daniel, Jacobs, Cindy, Stockler, Martin R., Higano, Celestia S., de Bono, Johann S., Chi, Kim N., Clark, Susan J., Horvath, Lisa Glen

Journal:

European Urology

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

17

Imaging Diagnosis and Follow-up of Advanced Prostate Cancer: Clinical Perspectives and State of the Art

Perez-Lopez, Raquel, Tunariu, Nina, Padhani, Anwar R., Oyen, Wim J. G., Fanti, Stefano, Vargas, Hebert Alberto, Omlin, Aurelius, Morris, Michael J., de Bono, Johann, Koh, Dow-Mu

Journal:

Year:

2019

Language:

english

File:

PDF, 4.09 MB

english, 2019

18

Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer

de Wit, Ronald, de Bono, Johann, Sternberg, Cora N., Fizazi, Karim, Tombal, Bertrand, Wülfing, Christian, Kramer, Gero, Eymard, Jean-Christophe, Bamias, Aristotelis, Carles, Joan, Iacovelli, Roberto,

Journal:

New England Journal of Medicine

Year:

2019

Language:

english

File:

PDF, 389 KB

english, 2019

19

Androgen Receptor Modulation Optimized for Response—Splice Variant: A Phase 3, Randomized Trial of Galeterone Versus Enzalutamide in Androgen Receptor Splice Variant-7–expressing Metastatic Castration-resistant Prostate Cancer

Taplin, Mary-Ellen, Antonarakis, Emmanuel S., Ferrante, Karen J., Horgan, Kerry, Blumenstein, Brent, Saad, Fred, Luo, Jun, de Bono, Johann S.

Journal:

European Urology

Year:

2019

Language:

english

File:

PDF, 2.36 MB

english, 2019

20

Systematic Review of Efficacy and Health Economic Implications of Real-world Treatment Sequencing in Prostate Cancer: Where Do the Newer Agents Enzalutamide and Abiraterone Fit in?

Pereira-Salgado, Amanda, Kwan, Edmond Michael, Tran, Ben, Gibbs, Peter, De Bono, Johann, IJzerman, Maarten

Journal:

European Urology Focus

Year:

2020

File:

PDF, 461 KB

2020

21

Prostate carcinogenesis: inflammatory storms

de Bono, Johann S., Guo, Christina, Gurel, Bora, De Marzo, Angelo M., Sfanos, Karen S., Mani, Ram S., Gil, JesÃºs, Drake, Charles G., Alimonti, Andrea

Journal:

Nature Reviews Cancer

Year:

2020

File:

PDF, 2.30 MB

2020

22

Flexible trial design in practice – dropping and adding arms in STAMPEDE: a multi-arm multi-stage randomised controlled trial

Matthew R Sydes, Nicholas D James, Malcolm D Mason, Noel W Clarke, Claire Amos, John Anderson, Johann de Bono, David P Dearnaley, John Dwyer, Gordana Jovic, Alastair Ritchie, Martin Russell, Karen San

Journal:

Year:

2011

Language:

english

File:

PDF, 130 KB

english, 2011

23

Expression profiling of CD133+ and CD133— epithelial cells from human prostate

Christopher J. Shepherd, Siân Rizzo, Ioanna Ledaki, Melissa Davies, Daniel Brewer, Gerhardt Attard, Johann de Bono, David L. Hudson

Journal:

Year:

2008

Language:

english

File:

PDF, 700 KB

english, 2008

24

A novel, spontaneously immortalized, human prostate cancer cell line, Bob, offers a unique model for pre-clinical prostate cancer studies

Gerhardt Attard, Sian Rizzo, Ioanna Ledaki, Jeremy Clark, Alison H.M. Reid, Alan Thompson, Vincent Khoo, Johann S. de Bono, Colin S. Cooper, David L. Hudson

Journal:

Year:

2009

Language:

english

File:

PDF, 593 KB

english, 2009

25

Preliminary study of the specific endothelin a receptor antagonist zibotentan in combination with docetaxel in patients with metastatic castration-resistant prostate cancer

Donald L. Trump, Heather Payne, Kurt Miller, Johann S. de Bono, Joe Stephenson III, Howard A. Burris III, Faith Nathan, Maria Taboada, Thomas Morris, Andreas Hubner

Journal:

Year:

2011

Language:

english

File:

PDF, 259 KB

english, 2011

26

A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma

Monica M. Mita, Eric K. Rowinsky, Leonardo Forero, S. Gail Eckhart, Elzbieta Izbicka, Geoffrey R. Weiss, Muralidhar Beeram, Alain C. Mita, Johann S. de Bono, Anthony W. Tolcher, Lisa A. Hammond, Paul

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 353 KB

english, 2007

27

Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study

Jordi Rodon, Mitchell Garrison, Lisa A. Hammond, Johann de Bono, Lon Smith, Leonardo Forero, Desirée Hao, Chris Takimoto, John M. Lambert, Lini Pandite, Maria Howard, Hongsheng Xie, Anthony W. Tolcher

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 377 KB

english, 2008

28

A phase I dose escalation study of the pharmacokinetics and tolerability of ZK 304709, an oral multi-targeted growth inhibitor (MTGI™), in patients with advanced solid tumours

Edwina N. Scott, Anne L. Thomas, L. Rhoda Molife, Samreen Ahmed, Sarah Blagden, Peter C. Fong, Kristin Kowal, Candice McCoy, Herbert Wiesinger, Will Steward, Johann De Bono

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 253 KB

english, 2009

29

Phase I and pharmacokinetic study of cisplatin and troxacitabine administered intravenously every 28

Chia-Chi Lin, Muralidhar Beeram, Eric K. Rowinsky, Chris H. Takimoto, Chee M. Ng, Charles E. Geyer, Louis J. Denis, Johann S. De Bono, Desiree Hao, Anthony W. Tolcher, Sun-Young Rha, Jacques Jolivet,

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 444 KB

english, 2009

30

Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma

Paul Haluska, Frank Worden, David Olmos, Donghua Yin, David Schteingart, Gretchen N. Batzel, M. Luisa Paccagnella, Johann S. de Bono, Antonio Gualberto, Gary D. Hammer

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 425 KB

english, 2010

31

Clinical benefit of early phase clinical trial participation for advanced sarcoma patients

Robin L. Jones, David Olmos, Khin Thway, Cyril Fisher, Nina Tunariu, Sophie Postel-Vinay, Michelle Scurr, Johann de Bono, Stan B. Kaye, Ian R. Judson

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 400 KB

english, 2011

32

Phase I and pharmacokinetic study of 3′-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies

Lisa A. Hammond-Thelin, Melanie B. Thomas, Michiko Iwasaki, James L. Abbruzzese, Yvonne Lassere, Christina A. Meyers, Paulo Hoff, Johann de Bono, Jody Norris, Hitoshi Matsushita, Akira Mita, Eric K. R

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 237 KB

english, 2012

33

Envisioning the future of early anticancer drug development

Yap, Timothy A., Sandhu, Shahneen K., Workman, Paul, de Bono, Johann S.

Journal:

Nature Reviews Cancer

Year:

2010

Language:

english

File:

PDF, 2.38 MB

english, 2010

34

Therapeutic Options for Advanced Prostate Cancer: 2011 Update

Aurelius Omlin, Johann S. de Bono

Journal:

Current Urology Reports

Year:

2012

Language:

english

File:

PDF, 177 KB

english, 2012

35

FGF Receptor Inhibitors: Role in Cancer Therapy

Gennaro Daniele, Jesus Corral, L. Rhoda Molife, Johann S. de Bono

Journal:

Current Oncology Reports

Year:

2012

Language:

english

File:

PDF, 308 KB

english, 2012

36

Steroid Hormone Receptors in Prostate Cancer: A Hard Habit to Break?

Gerhardt Attard, Colin S. Cooper, Johann S. de Bono

Journal:

Year:

2009

Language:

english

File:

PDF, 109 KB

english, 2009

37

Beyond Hormone Therapy for Prostate Cancer with PARP inhibitors

Johann Sebastian de Bono, Shahneen Sandhu, Gerhardt Attard

Journal:

Year:

2011

Language:

english

File:

PDF, 65 KB

english, 2011

38

Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development?

Craig P. Carden, Debashis Sarker, Sophie Postel-Vinay, Timothy A. Yap, Gerthardt Attard, Udai Banerji, Michelle D. Garrett, George V. Thomas, Paul Workman, Stan B. Kaye, Johann S. de Bono

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 856 KB

english, 2010

39

Abiraterone acetate: redefining hormone treatment for advanced prostate cancer

Carmel J. Pezaro, Deborah Mukherji, Johann S. De Bono

Journal:

Drug Discovery Today

Year:

2012

Language:

english

File:

PDF, 138 KB

english, 2012

40

New Therapies for Castration-Resistant Prostate Cancer: Efficacy and Safety

Himisha Beltran, Tomasz M. Beer, Michael A. Carducci, Johann de Bono, Martin Gleave, Maha Hussain, William K. Kelly, Fred Saad, Cora Sternberg, Scott T. Tagawa, Ian F. Tannock

Journal:

European Urology

Year:

2011

Language:

english

File:

PDF, 349 KB

english, 2011

41

Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer

Andrew Eichholz, Roberta Ferraldeschi, Gerhardt Attard, Johann S. de Bono

Journal:

Molecular and Cellular Endocrinology

Year:

2012

Language:

english

File:

PDF, 302 KB

english, 2012

42

Targeted agents in cancer therapy

Hendrik-Tobias Arkenau, Craig P. Carden, Johann S. de Bono

Journal:

Medicine (Medicine Publishing Company Ltd)

Year:

2008

Language:

english

File:

PDF, 183 KB

english, 2008

43

Granulocyte macrophage colony-stimulating factor and interleukin-3 regulate chemokine and chemokine receptor expression in bone marrow macrophages

David I Jarmin, Robert J.B Nibbs, Thomas Jamieson, Johann S de Bono, Gerard J Graham

Journal:

Experimental Hematology

Year:

1999

Language:

english

File:

PDF, 1.09 MB

english, 1999

44

Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma

Johann S de Bono, Anthony W Tolcher, Eric K Rowinsky

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 840 KB

english, 2003

45

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

Timothy A. Yap, Shahneen K. Sandhu, Craig P. Carden, Johann S. de Bono

Journal:

CA: A Cancer Journal for Clinicians

Year:

2011

Language:

english

File:

PDF, 994 KB

english, 2011

46

Changing Therapeutic Paradigms in Castrate-Resistant Prostate Cancer

Andrea Zivi, Christophe Massard, Johann De-Bono

Journal:

Clinical Genitourinary Cancer

Year:

2010

Language:

english

File:

PDF, 1.93 MB

english, 2010

47

Histone Deacetylase Inhibitors: Emerging Anticancer Therapeutic Agents?

Rebecca Kristeleit, Peter Fong, G. Wynne Aherne, Johann de Bono

Journal:

Clinical Lung Cancer

Year:

2005

Language:

english

File:

PDF, 1.08 MB

english, 2005

48

Optimizing the care of patients with advanced prostate cancer in the UK: current challenges and future opportunities

Heather Payne, Amit Bahl, Malcolm Mason, Janis Troup, Johann De Bono

Journal:

BJU International

Year:

2012

Language:

english

File:

PDF, 503 KB

english, 2012

49

Targeting CYP17: established and novel approaches in prostate cancer

Timothy A Yap, Craig P Carden, Gerhardt Attard, Johann S de Bono

Journal:

Current Opinion in Pharmacology

Year:

2008

Language:

english

File:

PDF, 371 KB

english, 2008

50

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

Timothy A Yap, Michelle D Garrett, Mike I Walton, Florence Raynaud, Johann S de Bono, Paul Workman

Journal:

Current Opinion in Pharmacology

Year:

2008

Language:

english

File:

PDF, 634 KB

english, 2008

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